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. 2012 Apr 26;11:42. doi: 10.1186/1475-2840-11-42

Table 2.

Relationship betweenCTGF −945 G/C genotypes and cardiac structure, cardiac function and kidney function parameters.

  −945 G/C genotypes     P values      
 
 GG
 GC
 CC
 Additive model (unadjusted)
 Additive model (adjusted)†
 Dominant model (adjusted)†
 Recessive model (adjusted)†
n
 161
 227
 107
  
  
  
  
Cardiac structure
  
  
  
  
  
  
  
LV mass index (g/m2)
 100.2 ± 26.3
 98.3 ± 28.2
 97.6 ± 23.2
 0.73
 0.43
 0.26
 0.90
Cardiac function
  
  
  
  
  
  
  
Diastolic function, E/A ratio
 1.00 ± 0.30
 1.00 ± 0.38
 1.01 ± 0.38
 0.94
 0.89
 0.84
 0.64
E/e´ ratio*
 10.00 [7.10 - 13.92]
 9.89 [7.53 - 19.00]
 9.74 [6.8 - 12.98]
 0.51
 0.55
 0.95
 0.35
Systolic function, LVEF (%)
 67 ± 11
 68 ± 12
 69 ± 10
 0.19
 0.32
 0.16
 0.33
Kidney function
  
  
  
  
  
  
  
eGFR (ml/min/1.73 m2)
 76.5 ± 25.9
 72.7 ± 25.8
 75.4 ± 25.3
 0.44
 0.19
 0.09
 0.98
24-hr urinary albumin excretion (μg/min) * 12.4 [8.2 - 44.0] 14.4 [7.8 - 47.8] 12.8 [8.6 - 35.2] 0.74 0.46 0.28 0.92

Data is expressed as mean ± SD, *Median [25th, 75th quartiles]. LVEF, left ventricle ejection fraction; eGFR, estimated glomerular filtration rate. †Genetic models are adjusted for age, gender, BMI, systolic and diastolic blood pressure and hypertension.