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. 2012 Jun 18;11:41. doi: 10.1186/1476-4598-11-41

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Copyright ©2012 O'Neill et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Axes 1 (horizontal) and 2 (vertical) of the unsupervised CIA for SKBR3 cell line data. A gene/TFBS frequency table produced with a PSSM threshold of 0.8 was used. Figure2(a) shows the projection of the cell line samples. The 0.1% DMSO treated samples (black 0 hr, red 2 hr, light blue 6 hr, light green 12 hr and orange 24 hr), are split from the 0.1 μM lapatinib treated samples (dark blue 6 hr, cyan 12 hr and dark green 24 hr) and the 1 μM lapatinib treated samples (purple 6 hr and pale blue 12 hr). The exception being the eight 0.1 μM lapatinib and 1 μM lapatinib treated samples at 2 hours post treatment coloured magenta and grey respectively. Figure,2(b) Shows the projection of the TFBS motifs. Motifs that are in the same orientation (direction from the origin) as a group of samples are associated with those samples.