Figure 4. DCG-IV acts presynaptically onto burst firing neurons.

(A1 and A2) EPSCs recorded in bursting neurons in response to paired-pulse stimulation before and in the presence application of DCG-IV. Representative example is shown in A1 and A2. The paired-pulse ratio is significantly increased after chemical activation of group II mGlu receptors. A summary of seven experiments is shown in (B). (C) Analysis of the squared coefficient of variation indicates a presynaptic mechanism by which DCG-IV exerts its action.