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. 2012 Sep 11;7(9):e45039. doi: 10.1371/journal.pone.0045039

Figure 5. DCG-IV increases failure ratio during minimal stimulation.

Figure 5

(A) Representative experiment for a burst firing neuron specific minimal stimulation. Overlays of 10 individual sweeps each are shown for control (ACSF) and 5 min after wash-in of DCG-IV (1 µM). (B) Minimal stimulation strength was achieved by stepwise increase of extracellular current injection by 0.5 nA. After establishing a stable EPSC/failure ratio for at least 10 min DCG-IV was applied. (C) Summary of all experiments showed a significant increase in the percentage of failure in the presence of DCG-IV (n = 6). Open circles represent experiments in the presence of the NMDA receptor antagonist APV (50 µM; for details see text).