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. 2012 Sep 11;7(9):e45039. doi: 10.1371/journal.pone.0045039

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© 2012 Kintscher et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Bursting and regular firing cells exhibited frequency facilitation. Changes in stimulation frequency from 0.05 Hz to 1 Hz (20 stimuli) resulted in a reversible facilitation of EPSCs. (B1) A typical experiment illustrating that the group II mGluR antagonist LY341495 (10 µM) did not have an effect on frequency facilitation in bursting cells. The results for nine such experiments (ACSF and LY341495) are summarized in (B2).