Table 1. Summary of the applied stimulation protocols to activate mGluRs.
Protocol | Pulse(s) analysed | ASCF | LY341495 | p |
20 pulses at 1 Hz | norm. 20th | 1.60±0.10 (9) | 1.76±0.16 (9) | >0.05 |
180 pulses at 1Hz | norm. 170th–180th | 1.51±0.15 (4) | 1.44±0.21 (4) | >0.05 |
75 pulses at 5 Hz | norm. 61th–75th | 1.73±0.11 (3) | 1.49±0.14 (3) | >0.05 |
10 pulses at 100 Hz + test stimulus | norm. test stimulus | 0.95±0.14 (5) | 0.83±0.21 (5) | >0.05 |
200 pulses at 200 Hz +2 test stimuli | norm. 1st test stimulus | 1.37±0.10 (6) | 1.36±0.09 (6) | >0.05 |
200 pulses at 200 Hz +2 test stimuli | PPD (2nd test stimulus/1st) | 0.67±0.04 (6) | 0.68±0.07 (6) | >0.05 |
PPD: paired-pulse depression.
paired t-test, one-tailed.