TABLE 3.
Analyses of NK cell depletion with anti-asialo GM1 antibody in the liver 2 days after infection with 400 sporozoites
| Mouse straina | % of NK cells (CD3+/DX5+) | Total no. of NK cellsb |
|---|---|---|
| BALB/c | ||
| Uninfected | 2.5 ± 0.6 | 4.2 ± 1.7† |
| Infected | 3.0 ± 0.2 | 4.4 ± 0.8* |
| Infected + anti-asialo GM1 | 1.3 ± 0.5 | 2.0 ± 0.6*† |
| IL-4−/− | ||
| Uninfected | 3.0 ± 0.6 | 5.3 ± 1.7‡ |
| Infected | 5.2 ± 2.1 | 8.9 ± 3.9*‡ |
| Infected + anti-asialo GM1 | 3.5 ± 0.2 | 5.4 ± 0.5* |
| IL-4rα−/− | ||
| Uninfected | 2.9 ± 0.6 | 5.1 ± 1.4‡ |
| Infected | 4.2 ± 1.0 | 7.4 ± 0.8*‡ |
| Infected + anti-asialo GM1 | 2.5 ± 0.6 | 4.6 ± 0.8* |
a
Each group contains four animals.
b
*, significantly different from the infected but normal rabbit serum-treated strain; †, significantly different from the uninfected and normal rabbit serum-treated strain; ‡, significantly different between the infected and uninfected groups (P < 0.05, Mann-Whitney U test).