TABLE 2.

Median ratios and 95% confidence intervals of antigen-specific IgG3 responses in villagers who were protected from clinical malaria but who had a low IgG3 response against either MSP3 or R0^a

Low IgG3 response antigenb	No. of villagers	Median antibody ratio (95% confidence interval) of IgG3 antibody responses to:
		MSP3	MSP1	R0	R1	R2
MSP3	7	1.2 (0.4-1.6)	1.2 (0.3-3.8)	10.4 (0.4-25.4)c	1.0 (0.1-1.7)	1.7 (0.3-43.0)
R0	15	10.0 (3.0-15.3)c	0.0 (0.0-1.9)	0.6 (0.3-0.7)	2.1 (0.5-3.8)	4.1 (1.3-7.8)c

^aNonparametric calculations of two-sided confidence intervals for the median were based on order statistics (the method provides a confidence interval for the upper and lower boundaries of the rank order of the value; the symmetric intervals whose confidence coefficients were 95% or more are indicated).

^bLow responders were defined as individuals with a specific IgG3 response below the lower 95% confidence interval limit of the median IgG3 ratio. The lower 95% confidence interval limits were 2.30 and 1.38 for MSP3 and R0, respectively.

^cThe specific median antibody ratio is significantly (P < 0.05) higher than the median IgG3 ratio for a similar-size group of age-matched susceptible individuals. P was determined by the Mann-Whitney U test.