Figure 6. GFP-actin transfection inhibits pressure-rate sensitive changes in cell mechanics.
The BSLS model was used to estimate the mechanical properties of transfected and non-transfected chondrocytes aspirated at two different pressure rates of 0.35 and 5.48 cmH2O/sec. Media and quartile values are shown for a) instantaneous modulus b) equilibrium modulus and c) viscosity. Statistically significant difference exist between transfected and non-transfected chondrocytes at 0.35 cmH2O/sec (*, p<0.05). For non transfected cells the moduli and viscosity were significantly greater at the slower aspiration rate (p<0.05).