TABLE 3.
Microarray dataa
| Change | Genes | Change (fold)
|
Ratio, single/pooled | |
|---|---|---|---|---|
| Single | Pooled | |||
| Upregulation | Early response genes | |||
| EGR3 | 20.8 | 17.9 | 1.2 | |
| MINOR | 16.9 | 10.2 | 1.6 | |
| TR3 | 14.2 | 11.0 | 1.3 | |
| NGFIB | 11.6 | 9.3 | 1.2 | |
| EGR1 | 4.0 | 2.7 | 1.5 | |
| EGR2 | 20.7 | 18.6 | 1.1 | |
| GOS8 | 4.7 | 5.3 | 0.9 | |
| GOS3 | 10.4 | 9.9 | 1.0 | |
| GOS2 | 13.8 | 12.7 | 1.1 | |
| PAC1 | 14.1 | 14.4 | 1.0 | |
| PC3 | 6.7 | 5.3 | 1.3 | |
| PPK | 4.8 | 3.8 | 1.3 | |
| C8FW | 4.7 | 4.6 | 1.0 | |
| Inflammatory cytokines and their targets | ||||
| TNFA | 4.7 | 5.9 | 0.8 | |
| IL1B | 5.1 | 4.7 | 1.1 | |
| MCSF1 | 7.4 | 7.1 | 1.0 | |
| COX2 | 17.8 | 15.8 | 1.1 | |
| HBEGF | 7.4 | 7.9 | 0.9 | |
| TSG6 | 4.1 | 4.8 | 0.8 | |
| MIP3A | 6.0 | 4.8 | 1.2 | |
| MIP1A | 8.8 | 12.7 | 0.7 | |
| SCYA2 | 5.3 | 6.5 | 0.8 | |
| MCP2 | 4.1 | 3.0 | 1.4 | |
| T. F. | 6.5 | 6.2 | 1.0 | |
| GROB | 8.4 | 6.7 | 1.2 | |
| Downregulation | CEBPA | 0.18 | 0.17 | 1.0 |
| IFNGR A chain | 0.40 | 0.50 | 0.8 | |
| P. C. | 0.15 | 0.20 | 0.7 | |
| CMYC | 0.32 | 0.20 | 1.3 | |
| Internal Controls | ACTB | 1.0 | 0.8 | 1.2 |
| PGK | 0.9 | 0.9 | 1.0 | |
| SCYLP | 1.2 | 0.9 | 1.3 | |
a
Changes in expression of individual genes in HL60 granulocytoids exposed to C. albicans at an MOI of 0.5:1 for an hour. Data are expressed as the ratio of expression in HL60 granulocytoids exposed to C. albicans over expression in HL60 granulocytoids. Data in the column single resulted from the ratios of expression in samples HL60 granulocytoid + candida single over HL60 granulocytoid single. Data in the column pooled resulted from the ratios of expression in samples H160 granulocytoid + candida pooled over HL60 granulocytoid pooled.