Table 1. Properties of RTB-specific mAbs produced in this study.
mAb | Isotype | SubD. | Epitope | KD [M] | Vero cells-IC50 µg/ml (nM) | THP-1 cells- apoptosis | Passive protection |
24B11a | IgG1 | 1α | 38–43 | 4.2×10−9 | 0.60 (4) | + | + |
SylH3b | IgG1 | n.d. | n.d | 3.38×10−9 | 0.75 (5) | + | + |
JB4 | IgG1 | n.d. | n.d. | 2.01×10−10 | 0.80 (5.3) | + | + |
B/J F9 | IgG1 | n.d. | n.d | 6.42×10−10 | 0.04 (0.27) | – | – |
C/M A2 | IgG1 | 2β | 194–198 | 2.2×10−9 | 5 (33) | – | – |
TFTB-1a | IgG1 | 2α | 169–184 | 5.63×10−9 | – | – | – |