TABLE 1.

Genetic control of immune responses in schistosomiasis

Parameter	Genetic loci	Observation(s)	Reference(s)
Epitope recognition	H-2	C3H and CBA Th cells show strong responses and C57BL/6 Th cells show a weak response to Sm-p40, a major SEA immunogen	56
		Opposite responses by these cells to 62-kDA SEA component	6
Antibody response	H-2	Different levels of antibody responses to different SEA immunogens in different mouse strains	74
Cellular immune responses	H-2	Th1-Th2 subset development differed in different mouse strains	7
	Non-H-2, more than one gene	HG size, fibrosis, and portal hypertension different in different mouse strains	20, 21, 36, 43