TABLE 2.
Regulation of HG inflammation in murine schistosomiasis by injection of antibodies to cytokines and cytokine receptors
| Species | Antibody specificity | Effects on granulomas
|
Reference | ||
|---|---|---|---|---|---|
| Size | Cellular composition | Fibrosis | |||
| S. mansoni | IL-2 | Decrease | Eosinophils decrease | 22 | |
| S. mansoni | IL-4 | None | Decrease | 26 | |
| S. japonicum | IL-4 | Increase | Decrease | 23 | |
| S. japonicum | IL-5 | Decrease | None | 25 | |
| S. mansoni | IL-5 | None | Eosinophils decrease | None | 125 |
| S. mansoni | IL-10 | Increase | Eosinophils increase | 40 | |
| S. mansoni | IL-10 | Increase | Eosinophils increase | 15 | |
| S. mansoni | IFN-γ | None | Eosinophils increase | None | 125 |
| S. japonicum | IFN-γ | Decrease | None | 28 | |
| S. mansoni | TNFα | Decrease | 71 | ||
| S. mansoni | IFN-γ receptor | Decrease | Decrease in epithelioid cells | 118 | |
| S. mansoni | IL-2 receptor | None | None | 22 | |
| S. japonicum | IL-2 receptor | Increase | Decrease in eosinophils | None | 27 |