Figure 3.

Histologic findings of experimental group 1 (0.05 mg/mL ErhBMP-2) at 4 weeks. (A) There appeared to be a mixture of newly formed bone from the surgically created defect and newly formed bone originating from bone graft materials. Newly formed bone from the surgically created defect is shown to be more mature whereas newly formed bone from the bone graft materials is still undergoing the mineralization process (×12.5). (B) Defect margin area: The arrowheads indicate the margin of the surgically created defect. The white asterisk indicates newly formed bone assumed to have originated from the defect margin (×50). (C) The Schneiderian membrane: The black asterisk indicates newly formed bone assumed to have originated from graft materials (×50). Note that immature woven bone is evident here in contrast to mature lamellar bone as indicated by the white asterisk in Fig. 3B. (D) Middle area: Immature woven bone can be seen (×50).