Figure 4.

Histologic findings of experimental group 1 (0.05 mg/mL ErhBMP-2) at 8 weeks. (A) When compared to the 4 week healing group, more vascularization is evident in the 8-week healing group (arrowheads). The surgically created defect was almost completely closed. The particle size of the graft materials is dramatically reduced (white asterisk). Note that mature lamellar bone (black asterisk) is evident in the newly formed bone found in between graft materials (×12.5). (B) Defect margin area: both inflammatory cells and blood vessels can be observed, as indicated by the arrows and the arrowhead, respectively. The black asterisk indicates matured lamellar bone (×50). (C) The Schneiderian membrane: The Schneiderian membrane was also thicker than that of the 4 week healing group (×50). (D) Middle area: More mature lamellar bone is identified in newly formed bone found in between the graft materials (×50).