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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2012 Jul 25;264(1):73–83. doi: 10.1016/j.taap.2012.07.019

Fig. 5.

Fig. 5

CYP4Z1 overexpression enhances angiogenesis and growth of T47D breast cancer xenografts in nude mice. Nude mice injected with T47D cells transfected with CYP4Z1 or vector. After 2 days, the mice were treated with or without HET0016 (2 mg/kg). (A) Primary xenograft tumor volume growth curves. (B) Selected images of xenograft tumors in different groups at the end of the experiment as shown in (A). (C) Average primary tumor weight for each group after growth for 2 weeks. (D) Average microvessel density (MVD) in primary tumors and around tumors was counted in a blinded manner (Capillary vessel number per HPF). Results are shown as mean ± S.D. (n=6). **P < 0.01 vs. vector control; ##P < 0.01 vs. T47D-CYP4Z1 groups.