Table 2.

Diagnostic performance of various non-invasive tests for the per-vessel-territory detection of ischaemia (FFR < 0.80*)

Test	N patients	Sensitivity	Specificity	PPV	NPV	Accuracy	Reference
ICA (quantitative)	79	57 %	69 %	49 %	76 %	65 %	Meijboom [35]
CTCA (quantitative)	79	45 %	79 %	54 %	73 %	67 %	Meijboom [35]
CTCA (visual)	79	94 %	48 %	49 %	43 %	64 %	Meijboom [35]
CTCA (visual)	107	75 %	95 %	76 %	94 %	91 %	Kajander [37]
CTCA (visual)	103	91 %	40 %	47 %	89 %	59 %	Koo [36]
MPI-SPECT	139	48–62 %	80–90 %	61–62 %	70–90 %	67–84 %	Forster [39], Melikian [40]
MPI-PET	107	95 %	92 %	78 %	98 %	92 %	Kajander [37]
MPI-MR	195	82 %–97 %	60–98 %	65–98 %	86–96 %	76–90 %	Kirschbaum [41], Watkins [43], *Lockie [42]
MPI-PET + CTCA	107	93 %	99 %	96 %	99 %	98 %	Kajander [37]
MPI-CT + CTCA	42	68 %	98 %	97 %	77 %	84 %	Ko [50]
CT-FFR	103	88 %	82 %	74 %	92 %	84 %	Koo [36]

The diagnostic performance on a per-vessel-territory level of various non-invasive tests for the detection of a stenosis with a fractional flow reserve (FFR) < 0.80 (*except for FFR < 0.75 in Lockie et al.)

As the reported diagnostic performance of the various tests varies considerably across studies, several CTCA studies have been listed separately and a range is reported for MPI-MR. Abbreviations as for Table 1. CT-FFR = CT fractional flow reserve