Table 1.
Patient Demographics and Clinical and Pathologic Data
| Acute Rej (n=56) | Control (n=33) | UC Tx (n=530) | p-value Rej vs. Total | p-value Rej vs. Ctrl | |
|---|---|---|---|---|---|
| Age | 39.3 ±13.9 | 51.6 ± 12.5 | 47.74 ± 15.1 | <0.0001 | <0.0001*** |
| Gender | |||||
| Male | 62.5% | 66.7% | 62.0% | 1.0 | 0.1* |
| Female | 37.5% | 33.3% | 38.0% | ||
| Race† | |||||
| African American | 75.0% | 44.0% | 51.6% | 0.006 | 0.001* |
| Caucasian | 19.6% | 48.0% | 31.7% | ||
| Hispanic | 5.4% | 8.0% | 13.8% | ||
| Diagnosis† | |||||
| Hypertension | 39.2% | 43.3% | 30.6% | 0.006 | 0.8* |
| Diabetes | 23.2% | 36.6% | 33.2% | 0.3 | 0.2* |
| FSGS | 10.7% | 6.7% | 6.4% | 0.4 | 0.3* |
| Lupus | 5.3% | 0% | 3.6% | 0.2 | 0.7* |
| Others | 32.1% | 33.3% | 27.0% | 0.3 | 1.0* |
| Follow-up Days | Mean ± SD (Median,) | ||||
|---|---|---|---|---|---|
| From Tx | 1517 ±1601 (1139) | 2370 ±1701 (1559) | 0.052** | ||
| From Tx to Bx | 949 ±1570 (366) | 1101 ±1678 (322) | 0.9** | ||
| From Bx | 568 ± 477 (440) | 1269 ±251 (1261) | <0.0001** | ||
| Mean ± SD | |||||
|---|---|---|---|---|---|
| Acute Rej | Control | ||||
| Interstitial fibrosis (ci score) | 1.2 ± 0.78 | 1.13 ± 0.18 | 0.5*** | ||
| Tubular atrophy (ct score) | 1.2 ± 0.82 | 1.13 ±0.18 | 0 4*** | ||
| GFR Pre-Bx | 51.7 ± 25.3 (49.0) | 48.4 ± 3.3 (46.0) | 0 4**** | ||
| GFR at Bx | 24.2 ± 12.6 (22.1) | 39.3 ± 3.7 (35.0) | 0.002**** | ||
| GFR at 4 weeks post-Bx | 31.4 ± 16.5 (31.0) | 40.0 ± 4.7 (42.0) | 0 1**** | ||
*
chi-square test.
**
Wilcoxon rank-sum test.
***
Mann-Whitney test.
****
2-tailed t-test.
†
For the acute rejection group, n=53 for this variable.
Abbreviations: Tx: transplant; Rej: rejection; Bx: biopsy; FSGS: focal segmental glomerulosclerosis; UC Tx: Total University of Chicago Transplants from 2004-2009.