FIG. 4.
Histopathological analysis of cardiac tissue from CD1 mice infected with a low dose of T. cruzi and treated with DNA vaccines. (A and B) Mice were infected with 5 × 102 T. cruzi parasites, treated with an intramuscular injection of a saline solution (A) or with 100 μg of DNA vaccine encoding TSA-1 (B) during the chronic phase on days 70 and 77 postinfection, and sacrificed on day 140 postinfection. The cardiac tissue of control mice had extensive inflammatory infiltrates, while that of DNA-treated mice had only mild diffuse inflammation. (C) Uninfected control CD1 mice.