Table 3.
Associations between GWAS breast cancer loci and lymph node involvement
| SNP | Controls | No cases | Yes cases | No vs. Yes OR (95 %CI) |
P value | Controls vs. No OR (95 %CI) |
P value | Controls vs. Yes OR (95 %CI) |
P value |
|---|---|---|---|---|---|---|---|---|---|
| rs1219648 | |||||||||
| AA | 146 | 62 | 111 | 1 | 1 | 1 | |||
| AG | 153 | 113 | 183 | 0.90 (0.60–1.36) | 0.6 | 1.74 (1.16–2.60) | 0.004 | 1.57 (1.12–2.21) | 0.006 |
| GG | 61 | 57 | 70 | 0.69 (0.42–1.13) | 0.1 | 2.20 (1.34–3.61) | 0.0008 | 1.51 (0.97–2.36) | 0.05 |
| G allele | 0.83 (0.65–1.06) | 0.1 | 1.55 (1.22–1.98) | 0.0002 | 1.29 (1.04–1.60) | 0.01 | |||
| rs2981582 | |||||||||
| GG | 140 | 44 | 94 | 1 | 1 | 1 | |||
| AG | 154 | 124 | 191 | 0.72 (0.46–1.12) | 0.1 | 2.56 (1.66–3.96) | 0.000006* | 1.85 (1.30–2.62) | 0.0003 |
| AA | 64 | 67 | 80 | 0.56 (0.33–0.93) | 0.01 | 3.33 (2.00–5.56) | 0.0000006* | 1.86 (1.20–2.90) | 0.003 |
| A allele | 0.76 (0.60–0.97) | 0.02 | 1.87 (1.47–2.39) | 0.0000002* | 1.43 (1.15–1.77) | 0.0008 | |||
| rs8051542 | |||||||||
| CC | 146 | 73 | 127 | 1 | 1 | 1 | |||
| CT | 176 | 115 | 150 | 0.75 (0.51–1.11) | 0.1 | 1.31 (0.89–1.92) | 0.1 | 0.98 (0.70–1.37) | 0.9 |
| TT | 46 | 46 | 86 | 1.07 (0.66–1.75) | 0.75 | 2.00 (1.18–3.39) | 0.005 | 2.15 (1.37–3.38) | 0.0004 |
| T allele | 1.00 (0.79–1.28) | 0.9 | 1.38 (1.09–1.77) | 0.006 | 1.39 (1.12–1.73) | 0.001 | |||
| rs12443621 | |||||||||
| GG | 98 | 69 | 110 | 1 | 1 | 1 | |||
| AG | 180 | 117 | 164 | 0.88 (0.59–1.31) | 0.5 | 0.92 (0.62–1.38) | 0.6 | 0.81 (0.57–1.16) | 0.2 |
| AA | 85 | 48 | 92 | 1.20 (0.74–1.96) | 0.43 | 0.80 (0.49–1.32) | 0.3 | 0.96 (0.63–1.47) | 0.8 |
| rs3803662 | |||||||||
| CC | 126 | 76 | 114 | 1 | 1 | 1 | |||
| TC | 165 | 102 | 169 | 1.10 (0.74–1.65) | 0.6 | 1.02 (0.69–1.52) | 0.8 | 1.13 (0.80–1.60) | 0.4 |
| TT | 78 | 57 | 84 | 0.98 (0.61–1.57) | 0.9 | 1.21 (0.76–1.94) | 0.3 | 1.19 (0.78–1.81) | 0.3 |
| rs889312 | |||||||||
| AA | 187 | 106 | 146 | 1 | 1 | 1 | |||
| AC | 151 | 97 | 178 | 1.33 (0.92–1.92) | 0.1 | 1.13 (0.79–1.63) | 0.4 | 1.51 (1.10–2.08) | 0.008 |
| CC | 31 | 32 | 42 | 0.95 (0.55–1.66) | 0.8 | 1.82 (1.02–3.27) | 0.03 | 1.74 (1.01–2.99) | 0.03 |
| C allele | 1.07 (0.83–1.37) | 0.5 | 1.28 (0.99–1.66) | 0.04 | 1.37 (1.10–1.72) | 0.004 | |||
| rs3817198 | |||||||||
| TT | 192 | 111 | 172 | 1 | 1 | 1 | |||
| CT | 147 | 96 | 157 | 1.06 (0.73–1.52) | 0.7 | 1.13 (0.79–1.62) | 0.4 | 1.19 (0.87–1.64) | 0.2 |
| CC | 32 | 28 | 38 | 0.88 (0.49–1.56) | 0.6 | 1.51 (0.83–2.74) | 0.1 | 1.33 (0.77–2.29) | 0.2 |
| rs13387042 | |||||||||
| AA | 115 | 84 | 118 | 1 | 1 | 1 | |||
| AG | 175 | 107 | 183 | 1.22 (0.83–1.79) | 0.2 | 0.84 (0.57–1.23) | 0.3 | 1.02 (0.72–1.44) | 0.9 |
| GG | 77 | 44 | 65 | 1.05 (0.64–1.74) | 0.8 | 0.78 (0.48–1.28) | 0.3 | 0.82 (0.53–1.28) | 0.3 |
| rs13281615 | |||||||||
| AA | 93 | 45 | 81 | 1 | 1 | 1 | |||
| AG | 176 | 116 | 165 | 0.79 (0.50–1.25) | 0.2 | 1.36 (0.87–2.13) | 0.1 | 1.08 (0.73–1.58) | 0.6 |
| GG | 96 | 74 | 120 | 0.90 (0.55–1.47) | 0.6 | 1.59 (0.97–2.61) | 0.05 | 1.44 (0.94–2.19) | 0.07 |
*P value < 0.0001 (cut-off for correction)