Diagram illustrates the architecture of the Lesion Tracking Application (LTA) and its supporting components. A PACS stores and displays the acquired images. A radiologist uses semantic annotation software on the workstation to generate an AIM XML file containing the image annotation metadata. The AIM files are stored in an XML database and made available for query and analysis by the LTA. The LTA retrieves information about lesions (eg, lesion name, location, and measurements) from the AIM XML database to produce lesion tracking summaries. In addition, the LTA accesses the corresponding annotated images in the PACS to display to the user, thereby streamlining the review of prior lesions and measurements.