Screen shot of the ePAD software used to generate image annotations that describe identified lesions. The radiologist outlines a lesion on the image, and the software computes relevant metrics, including diameter and area. The software also records geometric coordinates for the lesion and prompts the radiologist to provide an identifier, anatomic location, and type (eg, target, nontarget, new) for each lesion. The program then saves this information in the AIM format. Our software operates on AIM and demonstrates the usefulness of storing these annotations in a database. ROI = region of interest.