Table 1.
DAS28-CRP | SJC28 | TJC28 | VAS-GH | |||||
---|---|---|---|---|---|---|---|---|
Biomarker | Correlation | q Value | Correlation | q Value | Correlation | q Value | Correlation | q Value |
Calprotectin | 0.56 | <0.01 | 0.38 | <0.01 | 0.33 | <0.01 | 0.25 | <0.01 |
CCL22 | −0.04 | 0.75 | −0.13 | 0.19 | −0.03 | 0.73 | 0.01 | 0.94 |
CRP | 0.69 | <0.01 | 0.41 | <0.01 | 0.36 | <0.01 | 0.32 | <0.01 |
EGF | −0.07 | 0.46 | −0.08 | 0.42 | −0.12 | 0.28 | 0.02 | 0.94 |
ICAM-1 | 0.23 | 0.02 | 0.13 | 0.20 | 0.08 | 0.44 | 0.09 | 0.48 |
IL-1B | 0.45 | <0.01 | 0.34 | <0.01 | 0.31 | <0.01 | 0.27 | 0.03 |
IL-1RA | 0.01 | 0.97 | 0.05 | 0.58 | −0.09 | 0.44 | −0.03 | 0.94 |
IL-6 | 0.69 | <0.01 | 0.50 | <0.01 | 0.41 | <0.01 | 0.43 | <0.01 |
IL-6R | 0.01 | 0.97 | 0.03 | 0.71 | 0.02 | 0.89 | 0.08 | 0.53 |
IL-8 | 0.47 | <0.01 | 0.46 | <0.01 | 0.30 | <0.01 | 0.23 | 0.03 |
Leptin | 0.00 | 0.97 | −0.07 | 0.53 | −0.06 | 0.56 | 0.16 | 0.18 |
MMP-1 | 0.36 | <0.01 | 0.29 | <0.01 | 0.19 | 0.06 | 0.21 | 0.05 |
MMP-3 | 0.51 | <0.01 | 0.40 | <0.01 | 0.26 | <0.01 | 0.26 | 0.05 |
PYD | 0.23 | 0.04 | 0.29 | <0.01 | 0.21 | 0.09 | 0.12 | 0.39 |
Resistin | 0.22 | 0.03 | 0.13 | 0.20 | 0.13 | 0.28 | 0.10 | 0.43 |
SAA | 0.66 | <0.01 | 0.43 | <0.01 | 0.37 | <0.01 | 0.32 | <0.01 |
TNF-RI | 0.36 | <0.01 | 0.30 | <0.01 | 0.24 | 0.02 | 0.13 | 0.30 |
VCAM-1 | 0.13 | 0.24 | 0.14 | 0.20 | 0.08 | 0.56 | −0.03 | 0.79 |
VEGF-A | 0.29 | <0.01 | 0.18 | 0.12 | 0.07 | 0.56 | 0.14 | 0.18 |
YKL-40 | 0.42 | <0.01 | 0.35 | <0.01 | 0.30 | <0.01 | 0.15 | 0.18 |
Correlations are shown for all biomarkers with DAS28-CRP and individual components. q Values reflect the false discovery rate and are calculated by adjusting the p values for multiple hypothesis testing.
CCL22, C-C motif chemokine ligand 22; CRP, C reactive protein; DAS28-CRP, disease activity score based on 28 joints-CRP; EGF, epidermal growth factor; ICAM-1, inter-cellular adhesion molecule 1; IL, interleukin; IL-1B, IL-1 β; IL-1RA, IL-1 receptor antagonist; IL-6R, IL-6 receptor; MMP, matrix metallopeptidase; PYD, pyridinoline; SAA, serum amyloid A; SJC, swollen joint count; TJC, tender joint count; TNF-RI, tumour necrosis factor receptor type I; VAS-GH, visual analogue scale general health; VCAM-1, vascular cell adhesion molecule 1; VEGF-A, vascular endothelial growth factor A; YKL-40, cartilage glycoprotein 39.