Table 1.

Pearson correlations between individual biomarkers and clinical measures of disease activity

	DAS28-CRP		SJC28		TJC28		VAS-GH
Biomarker	Correlation	q Value	Correlation	q Value	Correlation	q Value	Correlation	q Value
Calprotectin	0.56	<0.01	0.38	<0.01	0.33	<0.01	0.25	<0.01
CCL22	−0.04	0.75	−0.13	0.19	−0.03	0.73	0.01	0.94
CRP	0.69	<0.01	0.41	<0.01	0.36	<0.01	0.32	<0.01
EGF	−0.07	0.46	−0.08	0.42	−0.12	0.28	0.02	0.94
ICAM-1	0.23	0.02	0.13	0.20	0.08	0.44	0.09	0.48
IL-1B	0.45	<0.01	0.34	<0.01	0.31	<0.01	0.27	0.03
IL-1RA	0.01	0.97	0.05	0.58	−0.09	0.44	−0.03	0.94
IL-6	0.69	<0.01	0.50	<0.01	0.41	<0.01	0.43	<0.01
IL-6R	0.01	0.97	0.03	0.71	0.02	0.89	0.08	0.53
IL-8	0.47	<0.01	0.46	<0.01	0.30	<0.01	0.23	0.03
Leptin	0.00	0.97	−0.07	0.53	−0.06	0.56	0.16	0.18
MMP-1	0.36	<0.01	0.29	<0.01	0.19	0.06	0.21	0.05
MMP-3	0.51	<0.01	0.40	<0.01	0.26	<0.01	0.26	0.05
PYD	0.23	0.04	0.29	<0.01	0.21	0.09	0.12	0.39
Resistin	0.22	0.03	0.13	0.20	0.13	0.28	0.10	0.43
SAA	0.66	<0.01	0.43	<0.01	0.37	<0.01	0.32	<0.01
TNF-RI	0.36	<0.01	0.30	<0.01	0.24	0.02	0.13	0.30
VCAM-1	0.13	0.24	0.14	0.20	0.08	0.56	−0.03	0.79
VEGF-A	0.29	<0.01	0.18	0.12	0.07	0.56	0.14	0.18
YKL-40	0.42	<0.01	0.35	<0.01	0.30	<0.01	0.15	0.18

Correlations are shown for all biomarkers with DAS28-CRP and individual components. q Values reflect the false discovery rate and are calculated by adjusting the p values for multiple hypothesis testing.

CCL22, C-C motif chemokine ligand 22; CRP, C reactive protein; DAS28-CRP, disease activity score based on 28 joints-CRP; EGF, epidermal growth factor; ICAM-1, inter-cellular adhesion molecule 1; IL, interleukin; IL-1B, IL-1 β; IL-1RA, IL-1 receptor antagonist; IL-6R, IL-6 receptor; MMP, matrix metallopeptidase; PYD, pyridinoline; SAA, serum amyloid A; SJC, swollen joint count; TJC, tender joint count; TNF-RI, tumour necrosis factor receptor type I; VAS-GH, visual analogue scale general health; VCAM-1, vascular cell adhesion molecule 1; VEGF-A, vascular endothelial growth factor A; YKL-40, cartilage glycoprotein 39.