Table 1.

Human sequences annotated with human structural templates

	Cluster (#)			PDB (#)	Cluster RMSD (Å)	Template sequence (#)	Annotated sequence (#)	Newly annotated sequence (#)	Annotated sequence (ID<30%)*
	$	^	°
Mg	8	1	0	9	-	9	55	54	1
Mg and Ions	7	1	0	9	0.30	8	53	52	6
Mg and Ligands	24	4	2	73	0.77	32	159	158	33
Mg , Ions and Ligands	22	5	4	57	0.52	31	1948	1947	19
Mixed	22	6	4	366	0.68	92	473	455	120
Total	83	17	10	514		172	2688	2666	179

Human sequences that inherit annotation from human structural templates are listed as a function of the different typologies of magnesium binding in the PDB files. The table lists the number of clusters, of structural templates, of annotated sequences (sequences that inherit Mg binding positions) according to our procedure, of sequences never annotated before as Mg binding proteins according to UniProtKB and of *sequences annotated when the target/template identity is below the 30%. Three different types of clusters are identified and listed in the first column: $ cluster with structures binding MG with a recognized functional role and whit an EC number, ^ clusters with structures binding MG with a recognized structural role (without an EC number), ° cluster containing structures (119 out of 1,341) binding MG without recognized physiological role.