Table 1.
Most significant immune loci from the association analyses
| SNP | Chr | Pos (Mb) | Region |
TDT |
PDT |
||||
|---|---|---|---|---|---|---|---|---|---|
| MA | T:U | OR (95% CI) | P-value | P-FDR | P-value | ||||
| rs7880807I |
X |
15.006 |
CD99L2 |
A |
190:299 |
0.64 (0.53-0.76) |
8.26E-07 |
- |
ND |
| rs13193457* |
6 |
15.346 |
JARID2 |
A |
139:229 |
0.61 (0.49-0.75) |
2.71E-06 |
- |
6.04E-05 |
| rs11796490 |
X |
150.058 |
CD99L2 |
G |
239:351 |
0.68 (0.58-0.80) |
4.01E-06 |
1.53E-02 |
NA |
| rs1514687 |
2 |
1.438 |
TPO |
A |
349:239 |
1.46 (1.24-1.72) |
5.72E-06 |
1.87E-02 |
4.49E-06 |
| rs10890518I | 2 | 1.435 | TPO | G | 356:249 | 1.43 (1.22-1.62) | 1.36E-05 | - | ND |
Chr, Chromosome; Pos., position; MA, minor allele; T:U, transmitted to untransmitted minor allele counts; OR, odds ratio; CI, confidence interval; P-FDR. False Discovery Rate-adjusted P-value; ND, test not done with imputed data; NA, not applicable, as the PDT does not handle chromosome X data. *This SNP had a 5% Mendelian error rate. IThis SNP was imputed.