Table 4.
Enrichment Analysis of Brain-Specific Markers
| Rank | PathwayID | PathwayName | N | Pvalue | AE | RE | MJI |
|---|---|---|---|---|---|---|---|
| 1 | 112315 | Transmission across Chemical Synapses | 190 | 0 | 27 | 17.26 | 0.2117 |
| 2 | 112316 | Neuronal System | 283 | 0 | 32 | 13.74 | 0.2232 |
| 3 | hsa04723 | Retrograde endocannabinoid signaling | 116 | 4.68E-14 | 18 | 18.85 | 0.1713 |
| 4 | 112314 | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | 136 | 4.48E-13 | 18 | 16.08 | 0.1599 |
| 5 | hsa04727 | GABAergic synapse | 98 | 5.48E-13 | 16 | 19.84 | 0.165 |
| 6 | hsa04080 | Neuroactive ligand-receptor interaction | 401 | 4.42E-12 | 26 | 7.88 | 0.1678 |
| 7 | 977441 | GABA A receptor activation | 12 | 7.38E-09 | 7 | 70.87 | 0.3281 |
| 8 | 975298 | Ligand-gated ion channel transport | 25 | 1.41E-08 | 8 | 38.88 | 0.2017 |
| 9 | 977443 | GABA receptor activation | 53 | 1.30E-07 | 9 | 20.63 | 0.1318 |
| 10 | hsa04724 | Glutamatergic synapse | 134 | 2.62E-07 | 12 | 10.88 | 0.1073 |
| 11 | 983712 | Ion channel transport | 61 | 3.20E-07 | 9 | 17.92 | 0.1206 |
| 12 | 420499 | Class C/3 (Metabotropic glutamate/pheromone receptors) | 15 | 5.19E-07 | 6 | 48.6 | 0.2313 |
| 13 | 888590 | GABA synthesis, release, reuptake and degradation | 19 | 1.52E-06 | 6 | 38.37 | 0.1891 |
| 14 | 399719 | Trafficking of AMPA receptors | 30 | 1.33E-05 | 6 | 24.3 | 0.1313 |
| 15 | 399721 | Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity | 30 | 1.33E-05 | 6 | 24.3 | 0.1313 |
| 16 | 112310 | Neurotransmitter Release Cycle | 36 | 3.03E-05 | 6 | 20.25 | 0.1146 |
| Rank | DiseaseID | DiseaseName | N | Pvalue | AE | RE | MJI |
| 1 | MESH:D001764 | Blepharospasm | 699 | 0 | 45 | 5.52 | 0.1398 |
| 2 | MESH:D012563 | Schizophrenia, Paranoid | 649 | 3.18E-12 | 40 | 5.29 | 0.1265 |
| 3 | MESH:D002385 | Cataplexy | 723 | 1.33E-11 | 41 | 4.86 | 0.1264 |
| 4 | MESH:D020187 | REM Sleep Behavior Disorder | 506 | 1.44E-11 | 34 | 5.76 | 0.1149 |
| 5 | MESH:D020821 | Dystonic Disorders | 837 | 4.52E-10 | 41 | 4.2 | 0.1226 |
| 6 | MESH:D015877 | Miosis | 1000 | 1.94E-09 | 44 | 3.77 | 0.1273 |
| 7 | MESH:D001925 | Brain Damage, Chronic | 1732 | 1.20E-08 | 59 | 2.92 | 0.1582 |
| 8 | MESH:D000341 | Affective Disorders, Psychotic | 700 | 1.50E-08 | 34 | 4.17 | 0.1056 |
| 9 | MESH:D007415 | Intestinal Obstruction | 1293 | 2.33E-08 | 48 | 3.18 | 0.1334 |
| 10 | MESH:D011681 | Pupil Disorders | 1612 | 2.61E-08 | 55 | 2.93 | 0.1486 |
| Rank | DrugID | DrugName | N | Pvalue | AE | RE | MJI |
| 1 | DB01595 | Nitrazepam | 20 | 2.92E-08 | 10 | 29.64 | 0.3294 |
| 2 | DB00349 | Clobazam | 19 | 4.26E-08 | 9 | 28.08 | 0.3083 |
| 3 | DB00475 | Chlordiazepoxide | 19 | 4.26E-08 | 9 | 28.08 | 0.3083 |
| 4 | DB00683 | Midazolam | 19 | 4.26E-08 | 9 | 28.08 | 0.3083 |
| 5 | DB00690 | Flurazepam | 19 | 4.26E-08 | 9 | 28.08 | 0.3083 |
| 6 | DB00842 | Oxazepam | 19 | 4.26E-08 | 9 | 28.08 | 0.3083 |
| 7 | DB01558 | Bromazepam | 19 | 4.26E-08 | 9 | 28.08 | 0.3083 |
| Rank | OrganID | OrganName | N | Pvalue | AE | RE | MJI |
| 1 | brain | brain | 363 | 0 | 260 | 15.42 | 0.8581 |