TABLE 1.
Serogroup C serum bactericidal antibody GMT with 95% CI and number of nonresponders with an SBA titer of <8, before and after one dose of MCC vaccine
| Group | Pre-MCC vaccination
|
Post-MCC vaccination
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| No. of patients | No. with SBA titer of <8 (%) | P value | No. of patients | GMT | 95% CI | P value | No. with SBA titer of <8 (%) | P value | |
| Asplenic | 90 | 67 (74) | 116 | 157.8 | 94.5-263.3 | 23 (20) | |||
| Sex | |||||||||
| Female | 43 | 35 (81) | 0.054 | 56 | 98.7 | 47.2-206.3 | 0.069 | 15 (27) | 0.08 |
| Male | 47 | 31 (66) | 60 | 244.4 | 119.6-499.5 | 8 (13) | |||
| Chronic illness | |||||||||
| Yes | 26 | 21 (81) | 0.38 | 35 | 84.4 | 30.9-230.8 | 0.13 | 10 (29) | 0.13 |
| No | 64 | 46 (72) | 80 | 199.1 | 109.4-362.4 | 13 (16) | |||
| Reason for removal of spleen | |||||||||
| Trauma | 38 | 25 (66) | 0.20 | 47 | 354.1 | 157.4-796.5 | 0.014 | 6 (13) | 0.15 |
| Medical | 46 | 36 (78) | 59 | 92.1 | 45.1-188.0 | 14 (24) | |||
| Time since splenectomy (yrs) | |||||||||
| <10 | 30 | 22 (73) | 0.90 | 35 | 75.0 | 27.7-203.2 | 0.054 | 12 (34) | 0.011 |
| ≥10 | 59 | 44 (75) | 80 | 222.9 | 122.3-406.0 | 11 (14) | |||
| Previous MACP | |||||||||
| Yes | 24 | 14 (58) | 0.038 | 35 | 98.9 | 37.7-259.6 | 0.30 | 7 (20) | 0.95 |
| No | 65 | 52 (80) | 78 | 179.4 | 95.7-336.2 | 16 (21) | |||
| Antibiotics | |||||||||
| Yes | 42 | 33 (79) | 0.40 | 54 | 185.7 | 90.5-381.2 | 0.56 | 8 (15) | 0.21 |
| No | 48 | 34 (71) | 62 | 136.9 | 65.1-287.6 | 15 (24) | |||
| Control | 48 | 25 (52) | 0.008b | 48 | 1448.2 | 751.1-2792.0 | <0.001a | 1 (2) | 0.003b |
a
Compared with all asplenic individuals.
b
Determined by Fisher's exact test of the results for the controls versus those for all asplenics.