TABLE 2.

Meningococcal serogroup C-specific IgG GMC with 95% CI prior to and following one dose of MCC vaccine

Group	Pre-MCC vaccination				Post-MCC vaccination
	No. of patients	ELISA GMC	95% CI	P value	No. of patients	ELISA GMC	95% CI	P value
Asplenic	90	1.1	0.7-1.6		118	9.4	6.7-13.3
Sex
Female	43	1.1	0.6-1.9	0.95	57	7.3	4.6-11.7	0.16
Male	47	1.1	0.6-2.0		61	11.9	7.2-19.8
Chronic illness
Yes	26	0.5	0.3-0.9	0.018	36	7.4	3.8-14.7	0.43
No	64	1.5	0.9-2.5		81	10.0	6.7-15.0
Reason for removal of spleen
Trauma	38	1.2	0.6-2.4	0.97	48	12.9	7.4-22.7	0.17
Medical reason	46	1.2	0.7-2.0		60	7.8	4.9-12.5
Time since splenectomy (yrs)
<10	30	1.3	0.6-2.8	0.58	36	7.2	3.7-14.1	0.30
≥10	59	1.0	0.6-1.6		81	10.7	7.1-16.1
Previous MACP
Yes	24	4.5	2.0-10.5	<0.001	35	10.1	5.0-20.0	0.75
No	65	0.7	0.4-1.0		80	8.9	6.0-13.4
Antibiotics
Yes	42	1.0	0.5-1.9	0.84	56	9.7	5.8-16.4	0.85
No	48	1.1	0.6-2.0		62	9.1	5.7-14.6
Control	48	1.5	0.8-2.6	0.40a	48	13.3	8.7-20.3	0.26a

^aCompared with all asplenic individuals.