Table 1.
NcRNAs specifically targeted by somatic genomic alterations in cancer.
Name | Class | Locus | Somatic alteration | Function | Cancer type | Reference |
---|---|---|---|---|---|---|
mir-15a/mir-16-1 | microRNA cluster | 13q14 | Deletion | Tumor suppressive | CLL | Calin et al. (2002) |
mir-17-92 | microRNA cluster | 13q31 | Amplification | Oncogenic | Lymphoma | Ota et al. (2004) |
LOC285194 and BC040587 | lncRNA | 3q13 | Deletion | Tumor suppressive | Osteosarcoma | Pasic et al. (2010) |
NC25 | lncRNA | 6q13 | Mutation | Tumor suppressive | Endometrial | Perez et al. (2008) |
GAS5 | lncRNA/snoRNA | 11q25 | Gene fusion | Unknown | B-cell lymphoma | Nakamura et al. (2008) |
PTENP1 | Pseudogene/lncRNA | 9p13 | Deletion | Tumor suppressive | Colon | Poliseno et al. (2010) |
SNORA42 | snoRNA | 1q22 | Amplification | Oncogenic | Lung | Mei et al. (2012) |
U50 | snoRNA | 6q14 | Mutation | Tumor suppressive | Prostate, breast | Dong et al. (2008, 2009) |