FIG. 10.

Correlation between antimannan IgG titers and the abilities of sera from individual donors to support opsonophagocytic killing of C. albicans by neutrophils. Yeast cells were incubated with neutrophils in the presence of 50% concentrations of untreated sera (both complement system and antimannan IgG intact) or heat-inactivated sera (complement system disabled and antimannan IgG intact). Results shown are from one experiment representative of two experiments with similar results obtained by using neutrophils from different donors. Reported antimannan titers reflect the use of 50% serum concentrations in the assay. Results are plotted as the number of CFU remaining after incubation versus the antimannan IgG antibody titer of each serum sample. Each data point represents the results for an individual serum sample that was untreated or heat inactivated.