TABLE 1.
Kinetics parameter | Value for classical pathwayb for:
|
P (A vs B) | Value for alternative pathwayc for:
|
P (A vs B) | ||
---|---|---|---|---|---|---|
Serotype A 36801 | Serotype B 36803 | Serotype A 36801 | Serotype B 36803 | |||
k′d | 0.18 ± 0.04 | 0.22 ± 0.05 | 0.011 | 0.05 ± 0.007 | 0.15 ± 0.03 | 0.011 |
t0e | −0.61 ± 0.69 | 0.65 ± 0.31 | 0.015 | 6.1 ± 1.0 | 6.2 ± 0.57 | 0.88 |
Results shown are the means ± standard deviations of results from four independent experiments. Analysis of each pair was done by Student's t test.
C3 deposition via the classical pathway was determined by incubation of C. albicans yeast cells in 40% untreated PHS.
C3 deposition via the alternative pathway was determined by incubation of C. albicans yeast cells in 40% PHS that had been treated with Mg-EGTA.
k′, pseudo first-order rate constant determined as described in the legend to Fig. 4.
t0, x intercept of a pseudo first-order rate plot. t0 is an estimate of the lag or induction period, in minutes, before the linear portion of the pseudo first-order rate plot begins (Fig. 4).