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. 2012 May 31;40(16):8033–8047. doi: 10.1093/nar/gks506

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Schematic depiction of biogenesis and the metabolism of mRNAs in human mitochondria. As mitochondrial RNA polymerase (POLRMT) transcribes mtDNA, the LRPPRC/SLIRP complex binds to the mRNA coding sequences of the long polycistronic precursor. tRNA 5′ and 3′ processing conducted by MRPP1,2,3 (48) and ELAC2 (49) generate mRNAs that are bound to the LRPPRC/SLIRP complex. The LRPPRC/SLIRP complex promotes mRNA polyadenylation by MTPAP. The LRPPRC/SLIRP complex protects mRNAs from 3′ exonucleolytic degradation mediated by PNPase and SUV3 helicase.