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. Author manuscript; available in PMC: 2013 Mar 15.
Published in final edited form as: Free Radic Biol Med. 2011 Dec 29;52(6):1067–1074. doi: 10.1016/j.freeradbiomed.2011.12.016

Fig. 6.

Fig. 6

Proposed mechanisms for 15 d-PGJ2 modulation of Mn-induced cytotoxicity. 15 d-PGJ2 modulates several cellular pathways in response to Mn treatment: it inhibits PI3K/Akt activation, suppresses NF-κB activation by blocking the phosphorylation of IKK, enhances Nrf2 activation in response to Mn-induced oxidative stress, and reverses the Mn-induced attenuation of DJ-1 expression.