Figure 7.

(a) Average ultrasound image intensity curves over four runs using the SiSTM imaging technique for targeted and non-targeted experiments. Intensity values for each trial were computed from 0.2 mm × 5.1 mm adherent microbubble ROI illustrated in Figure 4b. SiSTM imaging intensity values in targeted experiments were significantly higher than for non-targeted experiments. Water control results are not displayed in (a) but possessed essentially no change in intensity values above the noise. (b) Representative en face fluorescence microscopy images of DiI signal from targeted (top), non-targeted (middle), and water control (bottom) experiments. The relative DiI signal qualitatively correlates with the degree of adherent microbubble signal measured from SiSTM imaging. * indicates statistical difference using a two-tailed student’s t-test (p < 0.05).