FIG. 4.

In vivo radioisotope uptake of LNCaP xenografts. Tumor-bearing mice (n=4) were imaged at the time points shown after injection of 10⁹ pfu of virus. At each time point, mice were injected intraperitoneally with 0.5 mCi of ⁹⁹Tc and imaged by SPECT-CT 1 hr later. Intratumoral uptake was recorded by volume-of-interest analysis. (A) Cross-sectional views of intratumoral isotope concentration. (B) Radioisotope uptake kinetics over 3 weeks of imaging. p.i., post infection.