FIG. 5.

Efficacy of radiovirotherapy treatment. LNCaP-xenografted mice were injected intratumorally with 10⁹ pfu of the CRAd vectors or CRAd injection plus an intraperitoneal injection of 2 mCi of ¹³¹I 4 days later (n=10). (A) Tumor growth curves comparing mice treated with Ad5/3PB-ADP-hNIS and ¹³¹I versus control. (B) Kaplan-Meier curves of treated mice. Censored animals are indicated by tick marks. Significance of survival extension was determined by z tests of coefficients and standard errors generated by Cox Proportional Hazard Regression using controls as baseline.