Table 2.
Postprandial Plasma Levels of Proinsulin, Insulin, and Blood Glucose after a Standardized Meal in Patients with Type 2 Diabetes Mellitus and Healthy Subjectsa
| Patients with T2DM | ||||
|---|---|---|---|---|
| GLA + MET (n = 14) | SU + MET (n = 17) | DPP-4-I + MET (n = 17) | Healthy subjects (n = 17) | |
| Proinsulin AUC0–300 min (pmol/liter) | 4462 (3522–6363)b | 8256 (5662–10270)c,d,e | 4589 (3112–5645)b | 2758 (2152–3354) |
| Insulin AUC0–300 min (pmol/liter) | 7605 (5292–10990) | 14870 (11250–18863)b,d | 10200 (7700–13410)f | 6755 (5120–9923) |
| Blood glucose AUC0–300 min (mmol/liter) | 49330 (47195–56300)g | 48405 (44183–52168)g | 47640 (40350–52400)g | 33400 (31315–35355) |
a
Values are median (interquartile range).
b
p < .01 versus healthy subjects.
c
p = .003 versus GLA plus MET.
d
p = .01 versus DPP-4-I plus MET.
e
p = .034 versus DPP-4-I plus MET.
f
p = .011 versus healthy subjects.
g
p < .001 versus healthy subjects.