FIG. 3.

Antibodies against fungal melanin are produced during chromoblastomycosis. The reactivity of sera from healthy individuals (black bars) or patients with chromoblastomycosis (white bars) with melanin particles from culture fluids of conidia or sclerotic cells, as well as with cell-associated mycelial melanin, was tested by ELISA. The reactivity of patients’ sera was significantly higher than that of uninfected sera (P < 0.001). Results are expressed as means of three independent experiments ± standard deviations.