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. 2012 Apr 27;120(8):1088–1093. doi: 10.1289/ehp.1104684

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A single exposure to DE prevents HR recovery and causes decreased overall HRV in WKY rats during dobutamine challenge. Abbreviations: BL, baseline; bpm, beats per minute; R, reference. Values are presented as mean ± SE. Dobutamine dose-dependently increased HR in conscious/unrestrained WKY rats exposed to FA; this response was not significantly different in WKY rats exposed to DE; however, recovery HR was significantly higher in WKY exposed to DE when compared with those exposed to FA (FA controls) (A). At the highest dobutamine dose, the decrease in SDNN (B) was greater in DE-exposed WKY rats when compared with FA controls. RMSSD also decreased significantly at the highest dose (C). * p < 0.05 compared with FA controls; n = 5–6.