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. 2012 Apr 27;120(8):1088–1093. doi: 10.1289/ehp.1104684

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A single exposure to DE increases the peak HR response, decreases overall HRV, and prevents HR recovery in SH rats during dobutamine challenge. Dobutamine dose-dependently increased HR in conscious/unrestrained SH rats exposed to FA (A). Although the relative increase in HR at each dose of dobutamine was similar between FA- and DE-exposed animals, the peak HR at each dose (except 320 µg/kg) and at recovery were significantly increased in SH rats exposed to DE when compared with those exposed to FA (FA controls) (A). At the high dobutamine doses, the decrease in SDNN (B) was significantly greater in DE-exposed rats when compared with those exposed to FA. RMSSD was only significantly decreased in DE-exposed SH rats during the final recovery (C). Values are presented as mean ± SE. *p < 0.05 compared with FA controls; n = 5–6.