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Survival of mice following intraperitoneal challenge. Groups of at least 10 C57BL/6 mice were challenged intraperitoneally with 108 CFU of wild-type or GpoA− mutant S. pyogenes. Survival of mice was monitored daily for 9 days, and the data were presented as a Kaplan-Meier plot. The data indicate that the wild-type strain was significantly more lethal than the GpoA− mutant (P < 0.01).
