Table 2.

Comparison of Exposure to and Action of Insulin across Infusion Set Life

	Aspart alone			rHuPH20 pretreatment
	2 h after infusion set placement	74 h after infusion set placement	Change over 72 h of set use	2 h after infusion set placement	74 h after infusion set placement	Change over 72 h of set use	rHuPH20-mediated % reduction in variability over 72 h of set use
Early exposure (% of total in first 60 min)	15.0%	26.7% (p = .0004)	11.7%	31.0%	31.9% (p = .76)	0.9%	92%
Onset of action (early glucose infusion rate t50%)	60.0 min	29.9 min (p < .00001)	30.1 min	34.1 min	31.5 min (p = .73)	2.6 min	91%
Duration of action [AUMC(0–360)/AUC(0–360)]	180 min	156 min (p = .0005)	24 min	139 min	146 min (p = .28)	7 min	71%

AUMC, area under the first moment curve.