Table 2a.
Allergen described in egg, cow’s milk, soy, peanut
| Allergen Name | Allergen Common Name | Clinical Relevance | Allergen Name | Allergen Common Name | Clinical Relevance |
|---|---|---|---|---|---|
| Hen’s egg (Gallus domesticus) | Peanut (Arachis hypogea) | ||||
| Gal d 1 | Ovomucoid | Ara h 1 | Seed storage proteins | Heat stable | |
| Gal d 2 | Ovalbumin | Major allergen | Ara h 2 | Seed storage proteins | Heat stable, associated with anaphylaxis |
| Gal d 3 | Ovotransferrin/conalbumin | Ara h 3 | Seed storage proteins | ||
| Gal d 4 | Lysozyme | Ara h 4 | Seed storage proteins | ||
| Gal d 5 | α-Livetin | Bird-egg syndrome | Ara h 5 | Profilin (Bet v 2 like) | Cross-reactive with other plants; little clinical relevance |
| Cow’s milk | Ara h 6 | Seed storage proteins | Homology with Ara h 2. Allergy persists | ||
| Bos d 8 | α−, α.2-n, β-, γ1, γ2 γs K-casein |
Major allergen, heat stable | Ara h 7 | Seed storage proteins | |
| Bos d 4 | α-Lactalbumin | Major allergen, heat sensitive | Ara h 8 | Bet v 1 family (PR-1 O, Bet v 1 like) | Responsible for cross-reactivity with birch pollen analogues |
| Bos d 5 | β-Lactoglobulin | Major allergen, heat sensitive | Ara h 9 | LTP | Low prevalence of recognition in USA and north Europe; more common in south Europe |
| Bos d 7 | Immunoglobulin | Ara h 10 | Oleosin plant lipid storage bodies | ||
| Bos d 6 | BSA | Cross-reactivity with beef | Ara h 11 | Oleosin plant lipid storage bodies | |
| Soybean (Glycine max) | |||||
| Gly m 1 | LTP | ||||
| Gly m 2 | Defensin | ||||
| Gly m 3 | Profilin | ||||
| Gly m 4 | Bet v 1 family (PR-1 O, Bet v 1 like) | Cross-reactive with birch/peanut, mild oropharyngeal reaction | |||
| Gly m 5 | Vicilin | Severe reaction | |||
| Gly m 6 | Legumin | Severe reaction |
Abbreviations: BSA, bovine serum albumin; LTP, lipid transfer protein.