Table 3.
Analysis of Dallas Heart Study sequence data. Each entry represents a p-value from each method after adjusting gender and ethnicity. The selected ρ values by SKAT-O and rSKAT-O are presented in the parentheses. “ALL” indicates analysis results of joint test of all 93 variants in 3 genes
| Gene | SKAT-O | rSKAT-O | SKAT | rSKAT | N | W |
|---|---|---|---|---|---|---|
| Continuous TG level | ||||||
| ALL | 1.8×10−5 (ρ=0.1) | 4.6×10−5 (ρ=0.2) | 9.5×10−5 | 2.9×10−4 | 7.2×10−5 | 2.3×10−4 |
| ANGPTL3 | 2.6×10−3 (ρ=0.5) | 1.3×10−3 (ρ=1) | 8.9×10−3 | 6.2×10−3 | 1.1×10−3 | 1.9×10−3 |
| ANGPTL4 | 1.7×10−4 (ρ=0) | 8.5×10−4 (ρ=0.1) | 9.5×10−5 | 6.9×10−4 | 4.9×10−3 | 3.1×10−2 |
| ANGPTL5 | 3.4×10−1 (ρ=1) | 5.0×10−1 (ρ=1) | 7.6×10−1 | 8.5×10−1 | 3.3×10−1 | 2.0×10−1 |
| Dichotomous TG level | ||||||
| ALL | 1.1×10−4 (ρ=0.1) | 2.8×10−4 (ρ=0.1) | 1.4×10−4 | 2.4×10−4 | 2.2×10−3 | 2.7×10−3 |
| ANGPTL3 | 4.7×10−2 (ρ=0.4) | 3.2×10−2 (ρ=0.8) | 4.7×10−2 | 4.1×10−2 | 2.3×10−2 | 3.6×10−2 |
| ANGPTL4 | 1.6×10−4 (ρ=0) | 3.6×10−4 (ρ=0.1) | 9.4×10−5 | 3.3×10−4 | 3.1×10−3 | 2.2×10−2 |
| ANGPTL5 | 4.6×10−1 (ρ=0) | 3.1×10−1 (ρ=0) | 3.0×10−1 | 1.9×10−1 | 8.7×10−1 | 4.0×10−1 |