Table 1.

Explanatory power (R²) for the metabolite model in the simulation study for the mixed and linear models. The first 3 pathways contain differential signal, which in pathway 3 is of low intensity. Pathways 4–6 function as negative controls. The data used is simulated in its entirety and not based on the NCI-60 set.

Pathway	Mixed model	Linear model
1	0.879	0.776
2	0.883	0.828
3	0.875	0.430
4	0.158	5.67×10−5
5	0.183	2.2×10−3
6	0.114	1.21×10−4