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. 2012 Jun 14;13(4):748–761. doi: 10.1093/biostatistics/kxs016

Algorithm 1.

Model selection within a pathway

Preliminaries: Center and scale the data.

  1. Select active genes in pathway k.

  2. Regress the metabolites in pathway k on the active genes under regularization.

  3. Calculate a score (indicating level of activity) for pathway k.