Table 1. Performance of ELISA and PCR assays in Definite TBM subjects.a .
| PCR/ELISA | Sensitivityb | Specificityb | PPVb | NPVb | LR+ | LR− |
| qPCR | 100 (88;100) | 96 (91;99) | 84 (69;93) | 99 (96;100) | 23 (10;53) | 0.02 (0;0.27) |
| GlcB | 100 (88;100) | 96(91;99) | 84 (69;93) | 99 (96,100) | 23 (10;53) | 0.02 (0;0.27) |
| HspX | 100 (88;100) | 96 (91;99) | 84 (69;93) | 99 (96;100) | 23 (10;53) | 0.02 (0;0.27) |
| MPT 51 | 90 (73;98) | 98(95;100) | 93 (77;98) | 98 (93;99) | 58 (14;232) | 0.11 (0.04;0.31) |
| Ag 85B | 79 (60;92) | 97 (92;99) | 85 (67;94) | 95 (90;98) | 26 (10;68) | 0.21 (0.1;0.44) |
| PstS1 | 100 (88;100) | 97 (92;99) | 87 (72;94) | 99 (96;100) | 29 (11;71) | 0.02 (0;0.27) |
a
using cut-offs determined from ROC analysis of ELISA/qPCR data from ‘Definite’ TBM and NTIM groups (true positives and true negatives, respectively).
b
Values are in percentages, values in brackets denote 95% confidence intervals.