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. 2012 Sep 12;7(9):e45221. doi: 10.1371/journal.pone.0045221

Figure 1. Effect of TGF-β on MTX-induced apoptosis in Caco-2 cells.

Figure 1

Treatment of Caco-2 cells with MTX resulted in a significant increase in cell apoptosis compared to non-treated cells. Incubation of MTX-pre-treated Caco-2 cells with TGF-β (0.1 and 0.5 ng/ml) resulted in two-fold decrease in MTX induced cell apoptosis. Values are mean ± SEM. CONTR- control, MTX-methotrexate, TGF-β-transforming growth factor beta. *P<0.05 versus non-treated cells, †P<0.05 MTX-TGF-β 0.1 ng/ml and MTX- TGF-β 0.5 ng/ml versus MTX pretreated cells.