Figure 2. Principal components analysis (PCA) in non-users of HC.

In contrast to HC users, only three independent proteomic profiles were identified among non-users of HC, based on a loading score criterion of >0.5. No profile was characteristically representative of a negative or positive acute phase response. * designates the 19 proteins that were significantly different between users and nonhyphen;users in the whole study population. The arrows designate the direction of the difference (i.e. higher or lower levels of the protein) with respect to users.