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. 2012 Sep 12;7(9):e44441. doi: 10.1371/journal.pone.0044441

Table 2. The XRCC1 Arg194Trp and Arg280His polymorphisms on CC risk.

Variables Na Subgroup OR (95%CI) Pooled methods P b–heterogeneity P value P–Publication bias
Beggc Eggerd
Arg194Trp C/T
Trp/Trp vs Arg/Arg 5 All 2.21(1.60,3.06) Fixed M-H method 0.53 0.000 0.73 0.64
Arg/Trp vs Arg/Arg 5 All 1.23(1.02,1.49) Fixed M-H method 0.39 0.03 0.31 0.15
Dominant 5 All 1.36(1.14,1.63) Fixed M-H method 0.71 0.001 1.00 0.63
Recessive 5 All 2.06(1.51,2.82) Fixed M-H method 0.54 0.000 0.73 0.73
Arg280His G/A
His/His vs Arg/Arg 2 All(Asian) 1.60(0.74,3.44) Fixed M-H method 0.18 0.23 1.00 NA
Arg/His vs Arg/Arg 2 All(Asian) 1.03(0.81,1.32) Fixed M-H method 0.82 0.81 1.00 NA
Dominant 2 All(Asian) 1.07(0.84,1.36) Fixed M-H method 0.37 0.58 1.00 NA
Recessive 2 All(Asian) 1.59(0.74,3.41) Fixed M-H method 0.18 0.24 1.00 NA

NA, not application.

a

Number of comparisons.

b

P value of Q-test for heterogeneity test. Random-effects model was used when P value for heterogeneity test <0.1; otherwise, fixed-effects model was used.

c

P of Begg, P value of Begg rank correlation method for testing publication bias.

d

P of Egger, P value of Egger rank correlation method for testing publication bias.